Advanced Biotic

154 reviews

Six time-tested herbs that work in synergy to support the integrity of the microbiome and boost immune function.*

Advanced Biotic

Six time-tested herbs that work in synergy to support the integrity of the microbiome and boost immune function.*

154 reviews Write a Review
  • Promotes whole-body microbiome balance*
  • Secondary support for gut flora*
  • Offers respiratory, liver, and antioxidant support*
  • Supports immune function and helps maintain the natural healing systems of the body*
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  • Promotes whole-body microbiome balance*
  • Secondary support for gut flora*
  • Offers respiratory, liver, and antioxidant support*
  • Supports immune function and helps maintain the natural healing systems of the body*

Description Ingredients FAQ Reviews

Support Your Body’s Microbiome

Shortly after birth, you inherit microbes from your mother and the surrounding environment. The total of all the microbes that call your body home is called the microbiome. With more than 40,000 species possible and an infinite number of possible combinations, your microbiome is unique from every other person’s on the planet.

Though it was once thought that the microbes of the body were isolated mostly to the gut and skin, more recent research has revealed that ultra-low concentrations of microbes exist in all the tissues of your body — including your blood, heart, and even your brain.

Your health is very dependent on the health of your microbiome. As you go through life you continue to add microbes to your microbiome; maintaining a healthy immune system is essential for preserving the balance of “good” and “bad” microbes.

The herbs in Advanced Biotic work in two ways:

  1. They help maintain microbiome balance directly
  2. They support the immune system, which has the big job of managing the menagerie of microbes that inhabit the body.

"This has optimized my overall health. My immune function has significantly improved since taking this product over the past year."


Suggested Use:

For ongoing immune and microbiome support, take 3 capsules of the formulation once a day, ideally with food and plenty of liquid.

For more acute immune and microbiome support, increase servings to 3 capsules of the formulation twice daily, ideally with food and plenty of liquid, for as long as needed.

Consult your healthcare provider before using this product if you have a medical condition, are pregnant or nursing, or are taking medications.


Inside Advanced Biotic

Each ingredient in Advanced Biotic brings an impressive spectrum of benefits to the table. Combined, they provide comprehensive coverage with clinical grade herbs at serving sizes based as closely as possible on research and traditional use to ensure maximum efficacy for immune and microbiome support. These are herbs that Dr. Rawls has personally used and trusted for decades.

Advanced Biotic capsule with ingredient amounts
this product is gluten free, gmo free, vegetarian, peanut free, egg/dairy free

This product is also free from: Soy, Fish/Shellfish, BSE/TSE, Artificial Color & Flavor, Non-ETO/Non-Irradiated

Natural, Clinically-Studied Ingredients

AP-Bio™ Andrographis Extract (Andrographis paniculata)

Andrographis is a key herb for acute immune support. Traditional use and numerous modern studies support use of andrographis for periods when the immune system is under heavy strain. This herb supports the immune system and the gut microbiome, and helps bile flow and liver function to expedite removal of toxins from the body.*


Berberine is an isolated herbal constituent found in plants like Chinese coptis, barberry, and Oregon grape. It’s known for its powerful microbiome balancing activities, particularly in the gut. *

Cat’s Claw Extract (Uncaria tomentosa)

Native to Central and South America, this woody vine has a wide variety of traditional uses including immune support and microbiome balancing.*

Japanese Knotweed Extract (Polygonum cuspidatum)

Contains resveratrol and a wide spectrum of chemical compounds that support normal immune function and promote microbiome balance. Japanese knotweed, also promotes healthy cardiovascular function and has robust antioxidant activity.*

Garlic (Allium sativum)

A special form of garlic that has 10,000 ppm of active allicin per 200 mg serving. This remarkable ingredient supports the immune system and helps balance the microbiome. Garlic has long been used for targeted respiratory support in many traditional herbal traditions throughout the world.*

Sarsaparilla (Smilax medica)

Encourages natural removal of endotoxins and immune complexes to support the immune system and promote a healthy response to inflammation.*

Advanced Biotic Quality Standards

✔ Researched and formulated by Bill Rawls, MD

✔ Clinical-grade, optimally-dosed herbs

✔ Backed by science and a long history of traditional use

✔ Transparent labelling with no hidden ingredients or “proprietary blends”

✔ Independently lab tested for purity and potency

What’s Inside Matters

At Vital Plan, we pride ourselves on using clear, honest labeling. Advanced Biotic is quality-tested multiple times throughout the manufacturing process, then sent to third-party labs for verification of ingredient purity and label claims.

The serving sizes for each herb in this product match the corresponding research and traditional use as closely as possible to ensure maximum efficacy. In addition, the amounts of each herb are clearly indicated for you and your healthcare practitioner, so you know exactly what you are putting into your body.

"As a TCM (Traditional Chinese Medicine) practitioner and acupuncturist, I use Advanced Biotic and have had several patients on it. It is a nicely balanced herbal formula. I appreciate your product and will continue to refer my patients to it. I can tell you that I rarely recommend a new product line and after 25 years, I have seen a lot come and go. But this one is a great one!"




What is the recommended serving plan for this product?

For ongoing immune support, take 3 capsules of each formulation once a day, ideally with food and plenty of liquid.

For acute immune support when you feel like your immune system or microbiome is under increased strain, increase servings to 3 capsules of twice daily, ideally with food and plenty of liquid.

Consult your healthcare provider before using this product if you have a medical condition, are pregnant or nursing, or are taking medications.

When should I take Advanced Biotic?

For ongoing immune and microbiome support, simply take 3 capsules once a day. Ideally, take with food and a glass of water, in the morning.

For acute immune and microbiome support, increase the serving size to 6 capsules per day. You can take 3 with breakfast and 3 with dinner. Or, take 2 with breakfast, lunch, and dinner for more sustained immune and microbiome support throughout the day.

Should I take this product with food and liquids?
It’s ideal to take this product with food and water to increase activation and absorption of the ingredients. However, it’s not critical, and the majority of benefits will still be gained if taken without food or water.


When does this formulation usually start to work?

The herbs in Advanced Biotic get to work immediately. To maximize cumulative benefits for ongoing support, we recommend taking this product for at least 2-4 weeks, however, it may be taken longer if needed.

For acute immune support, take double the serving for 2-3 days, or longer as needed.

Do you have an autoship program?

Yes! When you join the Subscribe & Save autoship service, you’ll save 10% on recurring orders, save time, and never run out of supplements. We’ll send you an email notification before each delivery, and you can cancel or change your order anytime.

You can also choose to have shipments delivered every one, two, or three months, as best suits your needs. Simply select the Subscribe & Save option when you add an item to your shopping cart.


Is this product gluten-free?
Our products are 100% gluten-free.
Does this product contain caffeine or other stimulants?
This product does not contain caffeine or any other stimulants.
Is this product for women and men?
Yes, this formula is designed to benefit both women and men.
Why are there 3 capsules? Can I just take 1 capsule?

Dr. Rawls and the formulation team at Vital Plan suggest taking the full 3-capsule serving in order to get optimal benefits from these herbs. The serving sizes of each ingredient are based as closely as possible on the amounts shown to be effective in clinical use, research studies, and/or traditional use.

Some other products on the market may contain the same ingredients in this formulation, but at levels much too low to provide significant benefit. In some cases, other brands may have proprietary blends that prevent you from seeing how much of a certain ingredient you are receiving.

How is this product different from a probiotic?
The balance of bacteria within your gut and throughout your body is as unique to you as your fingerprint. So, while probiotic supplements provide “good” gut flora, there is no guarantee they will establish the right balance for your body and in addition, they may not be enough to balance out any “bad” microbes that may be present. The ingredients in Advanced Biotic do a good job of supporting your body to naturally maintain your unique whole-body microbiome balance and often negate the need for a probiotic.
Who formulates your products?
Each and every one of our products is formulated by Vital Plan co-founder and Medical Director, Dr. Bill Rawls. Dr. Rawls is a medical doctor with more than 30 years of clinical practice, and an herbal expert with more than 20 years of experience in the herbal and supplement industry. You can read more about him in our story.


How do I know Vital Plan products are safe?

Our extensive quality-control measures are documented on this website. Each of our products comes with an independent certificate of analysis verifying the ingredient identity, purity, and standardized constituents, where applicable. This includes testing for heavy metals, organic toxins, and microbiological contaminants.

We work closely with only select manufacturing partners who follow the highest GMP (Good Manufacturing Processes) guidelines, and each batch of products is tested thoroughly during the manufacturing process. We are passionate about quality, and we would never offer anything to the public that we would not take ourselves.

What if I am taking prescription medications or have a medical condition?
As with any new supplement, we recommend you check with your healthcare provider before using this product if you are taking medications.
Is this product safe for pregnant and breastfeeding women, or for couples trying to become pregnant?
Avoid use of this product while pregnant or breastfeeding, or if trying to become pregnant.
Are there any other contraindications?
Consult with your healthcare provider before starting any new supplement if you have any medical conditions.
Customer Reviews
4.8 Based on 154 Reviews
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United States United States
I recommend this product

Strange reaction

I can tolerate Advanced Biotic in small doses of one to three capsules per day, but more than that causes a feeling of stress in my brain and gives me a headache. I was told by Vital Plan staff to reduce the dosage, and that helps, but I’m not sure if this product helps since I was taking it in conjunction with all of the 3 other Restore Kit products for the treatment of chronic Lyme disease. Anyway, after 15 or 16 months on the Restore Kit, my energy has returned, so that I am able to do some work and exercise, so maybe the Restore Kit works. I still have trouble sleeping and cannot take the Vital Plan sleep product because I cannot tolerate melatonin. I know it sounds weird, but melatonin makes me cry uncontrollably. I read that can happen to people who are prone to depression which I have always been.


Vital Plan

Hi Cynthia. Thank you so much for your review. We are happy to know you are experiencing some improvements. Although you are taking a reduced serving that you tolerate of the Advanced Biotic formula it is still helping.

Alexis B.
United States United States
I recommend this product

Finally Relief for EBV and long Covid!

After years of searching and countless dollars spent on supplements/ Drs/ I am so grateful to Vital Plan for creating this blend. Its blend of adaptogens and herbs has given me relief and hope that I can manage my long Covid symptoms and subsequent emergent chronic Epstein Barr Virus. When my symptoms are acute I take 3/morning and 3/evening. It gives me energy, stops my shaking and dizziness and allows me to continue working and being a mother to my family. Thank you!

Lois R.
United States United States
I recommend this product


Hannah S.
United States United States
I recommend this product

It helps to fight off the invader viruses

Julie K.
United States United States
I recommend this product

Fantastic combination of ingredients!

I am on my second bottle of Advanced Biotic and I was genuinely grateful how easy it was to increase the capsules according to schedule and have no issues getting to the recommended dosage. As I continue this product I learn more and more about the individual ingredients and am grateful such excellent herbs were chosen to work so well together to promote health and wellbeing. Also, having Belinda and the team for support has been exactly what I needed to build great confidence and move forward with ease!


Vital Plan

Thank you, Julie, for your review of Advanced Biotic. How awesome that you continue to learn about the herbs in the formula and you have a growing appreciation for them as a result. I am happy you have been able to increase the serving without any issues and Belinda and the team have been supportive.

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Dr. Bill Rawls


Dr. Rawls' groundbreaking approach to wellness comes from decades of practicing medicine, extensive research in alternative therapies, and firsthand experience helping thousands find their path to wellness. Dr. Rawls is a best-selling author, Medical Director and Co-Founder of Vital Plan, a holistic health company and Certified B Corporation.

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